Last night I was up late (for me) - after midnight playing away. I have my defrag scheduler set to defrag all my hard drives starting at midnight. When trying to quicksave the hard drive went nuts, chattered for about 5 minutes, and I was informed that the program couldn't remove the temp file for the quicksave. I was able to auto-save (rest) and also save to an already created file, but was unable to quicksave until I deleted quicksave.ess after exiting the game and then reloading. My conjecture is that the defragger must must have working with the clusters in the quicksave.ess file somehow corrupting it.
Any thoughts? Has anyone else had a similar experience?
Points out the need for regularly saving apart from quicksave.