Drevin over at the official forums (and Skotte here at the Nexus Forums) points people to a patch on the SecuROM site along with these helpful pointers:
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Edit: Making it clear.
To Install
1- Right click on your DVD drive and select explore.
2- Double click on the setup.exe located in the DVD folder you just opened.
3- Follow install instructions.
To install the patch
1- Backup your old FalloutLauncher.exe by renaming it to FalloutLauncher.exe.old (located in the Fallout 3 folder)
2- Copy the new FalloutLauncher.exe in to place.
3- Launch the game form the new FalloutLauncher.exe (The patch won't work if you try to launch from either the Fallou3.exe or the DVD-Rom)
4- Play the game.



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